Research
Hormonal
Visceral adipose tissue (VAT) expression of complement C3 is inversely associated with insulin action, suggesting a specific mechanistic link between VAT inflammation and insulin resistance.
Complement C3 from visceral fat directly impacts insulin resistance. Reducing visceral fat through lifestyle changes is the most effective way to lower C3 levels and improve insulin sensitivity.
ModerateSupportsMEDIUM confidence
Insulin action related inversely to VAT complement C3 expression only.
Why this rating
Small sample size for the clamp subset (n=9), but uses gold-standard measurement.
Source
Subcutaneous and Visceral Adipose Tissue Gene Expression of Serum Adipokines That Predict Type 2 Diabetes
Katherine Samaras et al. · Obesity · 2009
DOI 10.1038/oby.2009.443
cross_sectional · n=16Cited 283×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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