Hormonal

In postmenopausal breast cancer survivors, higher adiposity (BMI, body fat mass, waist circumference) is significantly associated with higher circulating levels of estrone, estradiol, testosterone, and free testosterone, and lower levels of sex hormone-binding globulin (SHBG).

For postmenopausal breast cancer survivors, maintaining a healthy body weight is crucial because excess body fat directly increases levels of estrogen and testosterone, which can fuel cancer growth. While you cannot change your genetics, managing body fat through diet and physical activity may help lower these hormone levels, potentially improving your prognosis. Focus on overall fat reduction rather than just waist size, as total body fat mass is the key driver.