Hormonal
Higher plasma adiponectin levels are positively associated with greater insulin-stimulated glucose utilization (M) in adult women, independent of age, while adiponectin levels are negatively associated with visceral and subcutaneous abdominal fat.
For adult women, maintaining lower abdominal fat (visceral and subcutaneous) is associated with higher levels of adiponectin, a hormone that improves how your body uses glucose. While age itself does not lower adiponectin, the accumulation of abdominal fat often does. Focusing on reducing abdominal fat and improving insulin sensitivity may support healthier adiponectin levels.
Adiponectin is positively associated with M across the age span in women... Adiponectin levels were lower in the prediabetic women... Univariate correlations revealed significant negative relationships between plasma adiponectin levels and BMI, percent body fat, visceral fat, subcutaneous abdominal fat... and positive relationship with M
Why this rating
The study uses the hyperinsulinemic-euglycemic clamp, the gold standard for measuring insulin sensitivity, on a large, diverse cohort (n=148) with a wide range of BMI and age.
Source
Plasma Adiponectin and Leptin Levels, Body Composition, and Glucose Utilization in Adult Women With Wide Ranges of Age and Obesity
Alice S. Ryan et al. · Diabetes Care · 2003
DOI 10.2337/diacare.26.8.2383
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