Hormonal
Defective lipid storage capacity in white adipose tissue, often due to impaired expansion or PLIN dysfunction, leads to ectopic fat deposition in non-adipose tissues, causing insulin resistance and type 2 diabetes.
Your body relies on fat cells (adipose tissue) to safely store excess energy. If these cells cannot expand or function properly (due to genetics or chronic overloading), fat spills over into organs like the liver and muscles. This 'spillover' causes insulin resistance and type 2 diabetes. Therefore, maintaining healthy fat cell function is as important as reducing total fat mass.
Impairment of both white adipose tissue (WAT) lipid storage capacity and adipose tissue expansion... results in defective lipid homeostasis in nonadipose tissues, dyslipidemia and systemic insulin resistance.
Why this rating
Supported by clinical observations of lipodystrophies and genetic studies.
Source
The Perilipins: Major Cytosolic Lipid Droplet–Associated Proteins and Their Roles in Cellular Lipid Storage, Mobilization, and Systemic Homeostasis
Alan R. Kimmel et al. · Annual Review of Nutrition · 2016
DOI 10.1146/annurev-nutr-071813-105410
More from this paper
- Perilipin 1 (PLIN1) acts as a gatekeeper for lipid storage by sequestering lipases (ATGL and HSL) from cytosolic lipid droplets in the basal state, thereby suppressing lipolysis until hormonal stimulation triggers phosphorylation and enzyme recruitment.Strong
- PLIN2 and PLIN3 regulate lipid droplet hydrolysis in non-adipose tissues but are less effective barriers against lipases than PLIN1, and do not compensate for PLIN1 loss in white adipose tissue.Good
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