Research
Adherence
Exercise and caloric restriction can downregulate TLR2 and TLR4 expression and signaling, thereby reducing inflammation in obesity and metabolic syndrome.
Engage in regular, strenuous exercise and aim for weight loss through caloric restriction. These actions directly reduce the expression of inflammatory receptors (TLRs) on immune cells, helping to improve insulin sensitivity.
GoodSupportsHIGH confidence
Exercise can modulate inflammation. Previous studies have demonstrated that strenuous exercise significantly decreased surface expression of TLR2 and TLR4 on human monocytes in vivo... de Mello et al reported that improved insulin sensitivity after diet-induced weight loss was associated with down-regulation of TLR2 and TLR4 expression in PBMCs.
Why this rating
Supported by multiple human studies cited in Table 3.
Source
Toll-like Receptor Status in Obesity and Metabolic Syndrome: A Translational Perspective
Ishwarlal Jialal et al. · The Journal of Clinical Endocrinology & Metabolism · 2013
narrative_reviewCited 278×
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