Research
Hormonal
Adiponectin activates AMPK to promote fat oxidation and energy expenditure, while also increasing appetite via hypothalamic AMPK activation.
Adiponectin, a hormone from fat cells, helps burn fat in your muscles and liver. Interestingly, it may also signal your brain to eat, mimicking hunger hormones.
GoodQualifiesHIGH confidence
Adiponectin binds to... AdipoRI... activates AMPK, thus promoting fat oxidation in liver and muscle... Adiponectin also increases appetite by activating AMPK in the hypothalamus.
Why this rating
The paper cites specific studies for both effects, though the molecular mechanism of activation is unclear.
Source
AMPK: Regulating Energy Balance at the Cellular and Whole Body Levels
D. Grahame Hardie et al. · Physiology · 2014
DOI 10.1152/physiol.00050.2013
narrative_reviewCited 278×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- AMPK acts as a cellular energy sensor that restores homeostasis by activating catabolic pathways (ATP generation) and inhibiting anabolic pathways (ATP consumption) in response to energy stress.Strong
- The hormone ghrelin activates AMPK in the hypothalamus to increase appetite and food intake, whereas leptin and insulin inhibit AMPK to decrease appetite.Good
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