Hormonal
Overexpression of Insulin-like Growth Factor Binding Protein-2 (IGFBP-2) protects against the development of diet-induced obesity and insulin resistance by inhibiting adipogenesis.
While this study focuses on genetic overexpression in mice, it suggests that maintaining healthy levels of IGFBP-2 may support metabolic health. Future research may explore ways to naturally boost IGFBP-2, but for now, a balanced diet and regular exercise remain the most effective strategies for managing weight and insulin sensitivity.
Our findings demonstrate that IGFBP-2 exerts a beneficial effect in preventing both age and diet-induced obesity and its associated complications.
Why this rating
Strong evidence from transgenic mouse models and in vitro assays, but extrapolation to humans requires caution.
Source
IGF-Binding Protein-2 Protects Against the Development of Obesity and Insulin Resistance
Stephen B. Wheatcroft et al. · Diabetes · 2007
DOI 10.2337/db06-0436
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