Hormonal
Aging adipose tissue undergoes early structural and functional decline, characterized by visceral fat redistribution, loss of brown/beige fat, and accumulation of senescent cells, which drives systemic metabolic dysfunction and accelerates aging.
Your fat cells are not just storage; they are active organs that signal your body's health status. As you age, these signals can become harmful, leading to inflammation and metabolic issues. Maintaining healthy adipose tissue through balanced nutrition and activity is crucial for slowing down age-related decline.
Adipose tissue, which is the crucial energy reservoir and endocrine organ for the maintenance of systemic glucose, lipid, and energy homeostasis, undergoes significant changes during aging. These changes cause physiological declines and age-related disease in the elderly population.
Why this rating
This is a comprehensive review article citing numerous primary studies, though it synthesizes observational and animal model data rather than presenting new clinical trial results.
Source
Adipose tissue aging: mechanisms and therapeutic implications
Min‐Yi Ou et al. · Cell Death and Disease · 2022
DOI 10.1038/s41419-022-04752-6
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