Hormonal
Young men with high-normal blood pressure exhibit lower serum adiponectin, smaller LDL particle size, and higher resting heart rate compared to those with optimal blood pressure, independent of BMI.
If your blood pressure is in the 'high-normal' range (e.g., 130-139/85-89 mmHg), do not assume you are metabolically healthy. This state is associated with lower levels of protective adiponectin, less favorable LDL particle size, and higher resting heart rate compared to optimal blood pressure. Prioritize lifestyle interventions to improve insulin sensitivity and lower resting heart rate to mitigate the risk of progressing to type 2 diabetes and cardiovascular disease.
Young men with high-normal BP have a faster heart rate, lower serum adiponectin levels, and smaller LDL size than men with optimal BP, even after adjustment for BMI.
Why this rating
The study uses a homogeneous cohort of young, healthy men with controlled confounders (no meds, low smoking), but it is a cross-sectional observational study, not a randomized controlled trial.
Source
Young Men With High-Normal Blood Pressure Have Lower Serum Adiponectin, Smaller LDL Size, and Higher Elevated Heart Rate Than Those With Optimal Blood Pressure
Tsutomu Kazumi et al. · Diabetes Care · 2002
DOI 10.2337/diacare.25.6.971
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