Macro partitioning
Dietary interventions that substitute n-6 PUFA for trans-fatty acids (TFA) and saturated fatty acids (SFA) without simultaneously increasing n-3 PUFA produce a non-significant trend toward increased all-cause mortality.
Replacing trans and saturated fats with n-6 oils alone may slightly increase the risk of death from any cause, although this specific finding was not statistically significant. It reinforces the need to balance n-6 intake with n-3 sources.
RCT that substituted n-6 PUFA for TFA and SFA without simultaneously increasing n-3 PUFA produced an increase in risk of death that approached statistical significance (RR 1·16; 95 % CI 0·95, 1·42).
Why this rating
Meta-analysis of RCTs, though the p-value for all-cause mortality in n-6 specific groups was 0.15.
Source
<i>n</i>-6 Fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials
Christopher E. Ramsden et al. · British Journal Of Nutrition · 2010
DOI 10.1017/s0007114510004010
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