Hormonal
EPA supplementation (1-3 g/day) improves symptoms in various psychiatric disorders including depression, bipolar disorder, and schizophrenia, whereas DHA alone shows no effect on depression in tested trials.
If you are managing a psychiatric condition, discuss EPA supplementation (1-3g/day) with your doctor. The evidence suggests EPA is effective for mood disorders, whereas DHA alone has not shown similar benefits for depression. Note that very high doses of EPA (>=4g/day) may be less effective than moderate doses.
EPA at the dose of 1 or 2 g·day–1 has shown efficacy in reducing symptoms of treated depressive patients... In contrast, DHA showed no effect on depression in the two studies where it was tested as the only treatment
Why this rating
Based on a review of multiple randomized controlled trials summarized in the paper.
Source
Polyunsaturated fatty acids in the central nervous system: evolution of concepts and nutritional implications throughout life
Jean‐Marc Alessandri et al. · annales de biologie animale biochimie biophysique · 2004
DOI 10.1051/rnd:2004063
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- Supplementing infant formula with preformed DHA and AA, rather than just precursors, significantly improves mental development scores and visual acuity in infants compared to formulas containing only precursors.Good
- Low dietary intake of fish or n-3 PUFAs is associated with an increased risk of depression and Alzheimer's disease in older populations.Moderate
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