Adherence
Lifestyle interventions, specifically very low calorie diets (VLCD) leading to significant weight loss, can reverse defects in insulin signaling (PI3K, AS160, PKCλ/ζ) and improve insulin sensitivity in obese nondiabetic individuals.
For obese individuals without diabetes, a structured, short-term very low-calorie diet (600-800 kcal/day) can significantly improve how your muscles respond to insulin. This intervention reverses molecular defects in signaling pathways, leading to a 30% increase in glucose disposal. This suggests that significant weight loss can 'reset' insulin sensitivity at the molecular level.
VLCD treatment significantly increased IRS-1 tyrosine phosphorylation... insulin-stimulated IRS-1-associated PI3K activity was increased 2-fold post-treatment... impaired PKCλ/ζ activation in obese nondiabetic humans was reversed with weight reduction.
Why this rating
Based on specific human studies cited (Kim et al.) showing molecular changes post-VLCD.
Source
Molecular Mechanism of Insulin Resistance in Obesity and Type 2 Diabetes
Kang‐Duk Choi et al. · The Korean Journal of Internal Medicine · 2010
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