Hormonal
Moderate weight reduction (approx. 6% BMI decrease) shifts adiponectin oligomer composition toward high molecular weight (HMW) and medium molecular weight (MMW) forms, which are strongly correlated with increased HDL cholesterol.
If you are losing weight moderately (about 6% of body weight) through a balanced diet and moderate exercise, your body produces more of the 'high molecular weight' form of adiponectin. This specific form is linked to better HDL (good) cholesterol levels. You don't need extreme weight loss to see these specific hormonal benefits; a steady, moderate reduction is effective at shifting your adiponectin profile to support heart health.
In conclusion, weight reduction results in a relative increase of HMW/MMW adiponectin and a reduction of LMW adiponectin. Total adiponectin and especially HMW adiponectin are related to circulating HDL cholesterol.
Why this rating
Randomized controlled trial with a small sample size (n=17) but rigorous biochemical assays (Western blot) and metabolic clamps.
Source
Changes of Adiponectin Oligomer Composition by Moderate Weight Reduction
Thomas Bobbert et al. · Diabetes · 2005
DOI 10.2337/diabetes.54.9.2712
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