Hormonal
Stimulating the release of endogenous intestinal GIP via K-cell activation reduces food intake and body weight in mice through a central nervous system mechanism.
This research suggests that the hormone GIP, released from the gut after eating, plays a direct role in signaling satiety to the brain. While this is currently demonstrated via genetic manipulation in mice, it implies that therapies enhancing natural GIP release or mimicking its action could help reduce food intake and body weight, potentially offering an alternative or complement to GLP-1 based treatments.
These studies establish a physiological gut-brain GIP-axis regulating food intake in mice... The increase in GIP was associated with improved glucose tolerance, as expected, but also triggered an unexpected robust inhibition of food intake.
Why this rating
High-quality chemogenetic models in mice with rigorous controls (antagonists, intersectional models), but results are preclinical.
Source
Stimulating intestinal GIP release reduces food intake and body weight in mice
Jo E. Lewis et al. · Molecular Metabolism · 2024
DOI 10.1016/j.molmet.2024.101945
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