Hormonal
Citrus flavonoids (specifically nobiletin, diosmin, and 8-prenylnaringenin) demonstrate antidiabetic potential in vitro and in vivo by modulating glucose uptake, insulin sensitivity, and lipid metabolism through pathways such as PI3K/Akt, AMPK, and MAPK/ERK.
This paper reviews preclinical evidence that citrus flavonoids (like nobiletin and diosmin) may help manage blood sugar and lipids. However, it explicitly notes these effects have not yet been verified in human studies. Do not use these supplements to replace prescribed diabetes medication without consulting a physician.
These flavonoids regulated biomarkers of glycemic control, lipid profiles, renal function, hepatic enzymes, and antioxidant enzymes, and modulated signaling pathways related to glucose uptake and insulin sensitivity that are involved in the pathogenesis of diabetes and its related complications.
Why this rating
The evidence is derived from a systematic review of 38 in vitro and in vivo studies; however, human clinical trials were explicitly excluded from the review.
Source
Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies
Gopalsamy Rajiv Gandhi et al. · Nutrients · 2020
DOI 10.3390/nu12102907
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