Research
Hormonal
Skeletal muscle BMAL1 regulates sleep homeostasis and NREM sleep duration, demonstrating that peripheral tissue clocks influence central sleep processes.
Regular exercise helps synchronize your body's internal clocks, including those in your muscles, which in turn helps regulate your sleep duration and recovery. Consistent physical activity supports better sleep architecture.
GoodSupportsHIGH confidence
Rescuing Bmal1 in skeletal muscle was sufficient to restore NREM sleep amount as well as sleep recovery after sleep loss. A causative role for muscle Bmal1 was further supported by the fact that Bmal1 deletion only in skeletal muscle recapitulated the sleep alterations seen in whole-body Bmal1 KO mice.
Why this rating
Strong causal evidence in mouse models.
Source
Endocrine Crosstalk Between Skeletal Muscle and the Brain
Julien Delezie et al. · Frontiers in Neurology · 2018
DOI 10.3389/fneur.2018.00698
narrative_reviewCited 267×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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