Hormonal
The BodyTime assay, which estimates internal circadian time from a single blood sample using a small set of transcript biomarkers, achieves accuracy comparable to the gold standard dim-light melatonin onset (DLMO) method while being significantly less costly and time-consuming.
If you are interested in optimizing the timing of medications or health interventions (chronotherapeutics), you can now determine your internal circadian phase with a single blood test (BodyTime assay). This test is as accurate as the traditional gold standard (melatonin testing) but is much faster, cheaper, and does not require special lighting conditions. This allows for personalized timing of treatments based on your unique biological clock.
Our BodyTime assay uses a small set of blood-based transcript biomarkers to compute internal time with an accuracy equaling that of the current gold standard method at a smaller monetary and time cost.
Why this rating
The study uses a rigorous 3-stage biomarker development strategy with internal cross-validation and external validation on an independent cohort of 28 subjects, showing high correlation (r >= 0.9) with DLMO.
Source
High-accuracy determination of internal circadian time from a single blood sample
Nicole Wittenbrink et al. · Journal of Clinical Investigation · 2018
DOI 10.1172/jci120874
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