Hormonal

Leptin deficiency, whether genetic or acquired (e.g., lipodystrophy, hypothalamic amenorrhea), leads to severe metabolic and reproductive dysfunction, which can be reversed by leptin replacement therapy.

If you have very low body fat or a condition like lipodystrophy, your body may shut down non-essential functions like reproduction and metabolism because it thinks it is starving. Leptin therapy can reverse these effects, restoring fertility and metabolic health, even if you don't gain significant weight.