Hormonal
Methionine restriction (0.17% dietary methionine) reduces visceral fat mass and preserves insulin sensitivity in aging male rats independently of energy restriction.
This study suggests that restricting methionine intake to 0.17% of the diet can significantly reduce visceral fat and improve insulin sensitivity in aging male rats, independent of calorie intake. While this is a robust finding in rats, direct application to humans requires further research, as human metabolism and dietary requirements differ significantly from Fischer 344 rats.
Collectively, the results indicate that MR reduces visceral fat and preserves insulin activity in aging rats independent of energy restriction.
Why this rating
High-quality controlled animal study with pair-feeding controls, but results are specific to Fischer 344 rats.
Source
Methionine restriction decreases visceral fat mass and preserves insulin action in aging male Fischer 344 rats independent of energy restriction
Virginia L. Malloy et al. · Aging Cell · 2006
DOI 10.1111/j.1474-9726.2006.00220.x
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