Hormonal
Dietary intake of oleic acid (specifically via high-oleic peanut oil) reverses the inhibitory effect of the inflammatory cytokine TNF-α on insulin production and reduces blood glucose levels in type II diabetic models.
Incorporating foods high in oleic acid, such as specific high-oleic peanut oils or olive oil, may help mitigate the negative metabolic effects of chronic inflammation. For individuals with Type II Diabetes, this specific fatty acid profile appears to support insulin production where standard high-fat diets might not, potentially aiding in glucose regulation.
Oleic acid and peanut oil high in oleic acid were able to enhance insulin production in INS-1. TNF-α inhibited insulin production but pre-treatment with oleic acid reversed this inhibitory effect.
Why this rating
The study uses cell lines (INS-1) and a specific mouse model (KKAy), lacking human clinical trial data for generalizability.
Source
Oleic acid and peanut oil high in oleic acid reverse the inhibitory effect of insulin production of the inflammatory cytokine TNF-α both in vitro and in vivo systems
Evros Vassiliou et al. · Lipids in Health and Disease · 2009
DOI 10.1186/1476-511x-8-25
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