Research
Hormonal
Melatonin administration significantly reduces sleep-onset latency (SOL) in children with DSPD, but this effect is not statistically significant in adults.
Parents of children with DSPD may observe faster sleep onset with melatonin, whereas adults may not experience this specific benefit despite phase shifting.
GoodQualifiesMEDIUM confidence
The reduction in SOL with melatonin was statistically significant in children (by 16.04 min) but insignificant in adults (by 30.28 min).
Why this rating
Meta-analysis data, but heterogeneous results between adults and children.
Source
The Use of Exogenous Melatonin in Delayed Sleep Phase Disorder: A Meta-analysis
Ingeborg M. van Geijlswijk et al. · SLEEP · 2010
DOI 10.1093/sleep/33.12.1605
Meta-analysis · 9 studiesCited 264×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Exogenous melatonin advances sleep-wake rhythm and endogenous melatonin onset in patients with Delayed Sleep Phase Disorder (DSPD) when administered chronobiologically timed (approximately 5 hours prior to Dim Light Melatonin Onset).Good
- Incorrect timing or high doses of melatonin administered late relative to endogenous melatonin onset can result in no phase advance or even a delay in the circadian rhythm.Moderate
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