Hormonal
In postmenopausal women, higher trunk fat mass is a strong independent predictor of insulin resistance and dyslipidemia, whereas higher leg fat mass is favorably associated with these metabolic markers.
For postmenopausal women, focusing solely on total weight loss may miss the mark. Body composition analysis (like DEXA) can reveal if fat is accumulating in the trunk (high risk) or legs (protective). Managing trunk fat is critical for metabolic health, while leg fat may offer some protection against insulin resistance and poor lipid profiles.
Thus trunk fat is a strong independent predictor of insulin resistance and dyslipidemia in postmenopausal women, whereas leg fat appears to confer protective effects against metabolic dysfunction.
Why this rating
Observational study with rigorous control for confounders (leg/arm fat, age, menopause status) but no causal intervention.
Source
Contributions of total and regional fat mass to risk for cardiovascular disease in older women
Rachael E. Van Pelt et al. · American Journal of Physiology-Endocrinology and Metabolism · 2002
DOI 10.1152/ajpendo.00467.2001
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