Hormonal
Acute insulin deprivation in type 1 diabetes causes significant perturbations in metabolic pathways, specifically elevating ketones, lactate, branched-chain amino acids, and oxidative stress markers, while simultaneously decreasing mitochondrial ATP production capacity.
In type 1 diabetes, missing or withholding insulin leads to a complex metabolic state involving high blood sugar, ketone production, and muscle breakdown. This is not just about high glucose; it involves significant stress on the body's energy systems and increased oxidative stress. Managing insulin levels is critical to preventing these widespread metabolic disruptions.
Further analysis of metabolite levels measured by the two analytical techniques indicates several known metabolic pathways that are perturbed in T1D (I-) (protein synthesis and breakdown, gluconeogenesis, ketogenesis, amino acid oxidation, mitochondrial bioenergetics, and oxidative stress).
Why this rating
High-quality metabolomics data from a controlled clinical study with matched controls.
Source
Quantitative Metabolomics by 1H-NMR and LC-MS/MS Confirms Altered Metabolic Pathways in Diabetes
Ian R. Lanza et al. · PLoS ONE · 2010
DOI 10.1371/journal.pone.0010538
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