Hormonal
Coadministration of glucagon and GLP-1 increases resting energy expenditure by approximately 150 kcal/day and ameliorates hyperglycemia through a synergistic insulinotropic effect.
This research suggests that combining glucagon and GLP-1 hormones can boost your body's resting energy expenditure by about 150 calories per day without causing the high blood sugar spikes typically associated with glucagon. This happens because GLP-1 helps your body release more insulin, which balances out the glucose rise. While this was an acute study in healthy overweight individuals, it supports the development of dual-agonist drugs for treating obesity and type 2 diabetes.
Resting EE increased significantly during glucagon infusion by a mean of 146.99 kcal/day. This effect was retained when GLP-1 and glucagon were infused in combination, with a mean increase in resting EE of 146.26 kcal/day.
Why this rating
Randomized, double-blinded crossover study in humans, though with a small sample size (n=10) and acute duration (45 min).
Source
Coadministration of Glucagon-Like Peptide-1 During Glucagon Infusion in Humans Results in Increased Energy Expenditure and Amelioration of Hyperglycemia
Tricia Tan et al. · Diabetes · 2012
DOI 10.2337/db12-0797
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