Hormonal
The direct pathway (glucose -> UDP-glucose -> glycogen) accounts for 46-68% of hepatic glycogen synthesis postprandially, with the proportion increasing in the later stages (4-6 hours) after a meal.
After eating, your liver primarily makes glycogen directly from the glucose in your food (46-68% of the process), rather than from other precursors. This direct route becomes even more dominant in the hours following the meal.
The calculated contribution of the direct pathway to overall glycogen synthesis was 46±5 and 68±8% for each time period, respectively.
Why this rating
Relies on acetaminophen as a noninvasive probe, which is a validated but indirect method compared to direct biopsy.
Source
Direct assessment of liver glycogen storage by 13C nuclear magnetic resonance spectroscopy and regulation of glucose homeostasis after a mixed meal in normal subjects.
Roy Taylor et al. · Journal of Clinical Investigation · 1996
DOI 10.1172/jci118379
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