Hormonal
Reactive oxygen species (ROS) function as essential signaling molecules that mediate stress responses and adaptation, rather than solely as damaging agents, a concept known as the 'gradual ROS response hypothesis'.
Understand that some oxidative stress is normal and necessary. Your body uses ROS as signals to adapt to stress, such as exercise or dietary restriction. Do not try to eliminate all ROS with high-dose antioxidants, as this may interfere with these beneficial signaling pathways. Embrace mild stressors that trigger adaptive responses.
ROS are essential signalling molecules that mediate stress responses in general and the stress response to age-dependent damage in particular.
Why this rating
Based on multiple studies showing ROS involvement in stress response, autophagy, and adaptation.
Source
The role of mitochondrial <scp>DNA</scp> mutations and free radicals in disease and ageing
Marie Lagouge et al. · Journal of Internal Medicine · 2013
DOI 10.1111/joim.12055
More from this paper
- Modulating reactive oxygen species (ROS) levels through antioxidant interventions does not consistently extend lifespan or delay age-related diseases, contradicting the mitochondrial free radical theory of ageing.Good
- Mitochondrial DNA (mtDNA) mutations accumulate with age primarily due to replication errors rather than oxidative damage, and while high levels of mutations can cause premature ageing, normal levels may not be the primary driver of ageing.Good
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