Research
Hormonal
Peripheral administration of alpha-MSH restores the feeding rhythm and induces weight loss in mPer2-deficient mice by compensating for the disrupted hypothalamic alpha-MSH pulse.
For individuals with circadian eating disorders like night-eating syndrome, restoring the body's natural alpha-MSH rhythm might be key. This study shows that replacing this hormone can reduce food intake and weight, even on a high-fat diet. This supports the potential for targeted hormonal therapies for circadian-based obesity.
GoodSupportsHIGH confidence
Peripheral injection of alpha-MSH, which has been shown to enter the brain, restored the feeding rhythm and induced weight loss in mPer2-/- mice.
Why this rating
Clear cause-and-effect demonstrated in controlled animal trials.
Source
The Role of mPer2 Clock Gene in Glucocorticoid and Feeding Rhythms
Shutong Yang et al. · Endocrinology · 2009
DOI 10.1210/en.2008-0705
mechanism_onlyCited 260×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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