Hormonal
The AMPKα1 isoform plays a critical role in stimulating anabolism and regulating satellite cell dynamics during muscle regeneration, distinct from the catabolic role of AMPKα2.
Muscle repair after injury relies on specific molecular signals (AMPKα1) that are different from those that limit growth during stress. While general AMPK activation can hinder growth, the specific activation of the α1 isoform is necessary for stem cells to repair damage. This suggests that recovery protocols should support, not suppress, this specific signaling pathway.
Together, the current data indicate that AMPK does play an important role in regulating muscle mass and regeneration, with AMPKα1 playing a prominent role in stimulating anabolism and in regulating satellite cell dynamics during regeneration, and AMPKα2 playing a potentially more important role in regulating muscle degradation during atrophy.
Why this rating
Supported by genetic knockout studies showing impaired regeneration in AMPKα1-KO mice.
Source
The Role of AMPK in the Regulation of Skeletal Muscle Size, Hypertrophy, and Regeneration
David M. Thomson · International Journal of Molecular Sciences · 2018
DOI 10.3390/ijms19103125
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