Research
Hormonal
Adding progestins to oestrogen therapy enhances the protective effect against hip fractures compared to oestrogen alone, allowing for lower oestrogen doses.
If you are considering hormone replacement therapy (HRT) for hip fracture prevention, adding progestins to oestrogen may provide greater protection than oestrogen alone. This combination may also allow for lower doses of oestrogen. Discuss the benefits and risks of combined therapy with your healthcare provider.
GoodSupportsHIGH confidence
The addition of progestins permitted use of lower doses of oestrogens... Combined oestrogen-progestin regimens conferred lower odds ratios than oestrogens alone.
Why this rating
Based on the same large case-control study with detailed regimen data.
Source
Hormone replacement therapy and risk of hip fracture: population based case-control study
Karl Michaëlsson et al. · BMJ · 1998
DOI 10.1136/bmj.316.7148.1858
case_control · n=4589Cited 259×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Current use of hormone replacement therapy (HRT) with medium potency oestrogens significantly reduces the risk of hip fracture in postmenopausal women, with risk decreasing by 6% per year of use.Good
- The protective effect of HRT on hip fracture risk diminishes significantly if treatment is stopped for more than five years, regardless of prior duration of use.Good
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