Hormonal
A 10-week hypocaloric diet in obese subjects decreases the expression of lipolytic enzymes ATGL and HSL, potentially hindering further fat loss.
When you lose weight through dieting, your body may respond by reducing the enzymes (ATGL and HSL) responsible for breaking down fat. This biological adaptation can make subsequent weight loss harder. To overcome this, strategies that improve insulin sensitivity or preserve muscle mass (which may influence these enzymes) might be necessary to prevent this down-regulation.
Weight reduction significantly decreased ATGL and HSL mRNA and protein expression.
Why this rating
Interventional study with clear before/after measurements in a human cohort.
Source
Adipose Triglyceride Lipase and Hormone-Sensitive Lipase Protein Expression Is Decreased in the Obese Insulin-Resistant State
Johan W. E. Jocken et al. · The Journal of Clinical Endocrinology & Metabolism · 2007
DOI 10.1210/jc.2006-1318
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