Research
Macro partitioning
Short-chain fatty acids (SCFAs), particularly butyrate, exert anti-inflammatory effects by promoting macrophage polarization to the M2 phenotype and inhibiting NF-κB activation.
Eat more fiber-rich foods (vegetables, whole grains) to feed your gut bacteria. They produce short-chain fatty acids (SCFAs) like butyrate, which help calm inflammation by switching immune cells to a healing (M2) state. This is especially important if you have inflammatory conditions.
ModerateSupportsMEDIUM confidence
Butyrate is the most important SCFA due to its role in antagonizing colonic inflammation... butyrate can exert an anti-inflammatory effect in part by suppressing the activation of NF-κB... butyrate has the ability to exhibit anti-inflammatory activity on intestinal macrophages... by inducing the expression of IL-10.
Why this rating
Based on a review of multiple studies, including in vitro and animal models.
Source
The Relationship Between Gut Microbiota and Inflammatory Diseases: The Role of Macrophages
Ji Wang et al. · Frontiers in Microbiology · 2020
DOI 10.3389/fmicb.2020.01065
narrative_reviewCited 258×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
Related findings · Macro partitioning
- Total daily protein intake of 1.6 g/kg/day is sufficient for maximizing resistance training-induced muscle gains, with an upper confidence interval of 2.2 g/kg/day.Strong
- Resistance exercise training combined with sufficient dietary protein intake acts synergistically to maximize skeletal muscle hypertrophy, with protein intake saturating around 1.6 g/kg/day for general populations and potentially requiring 2.0-2.2 g/kg/day for resistance-trained individuals.Strong
- Trans fats should be completely eliminated from the diet, as they increase LDL cholesterol, decrease HDL cholesterol, and are directly associated with increased coronary risk.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →