Research
Hormonal
Semaglutide (2.4 mg/week) improves physical function and reduces body weight in patients with heart failure with preserved ejection fraction (HFpEF) and obesity.
If you have heart failure with preserved ejection fraction and obesity, semaglutide (2.4 mg weekly) can help you feel better, walk further, and lose weight. It is taken as a weekly injection, starting at a low dose to minimize side effects.
StrongSupportsVERY_HIGH confidence
Analysis of the dual primary endpoints showed a mean change in the KCCQ-CSS at week 52 of 13.7 points in the semaglutide group... and a significant reduction in body weight at week 52 of 9.8% in the semaglutide group
Why this rating
Based on a randomized, placebo-controlled trial (STEP-HFpEF DM) with clear statistical significance.
Source
CVOT summit report 2024: new cardiovascular, kidney, and metabolic outcomes
Oliver Schnell et al. · Cardiovascular Diabetology · 2025
DOI 10.1186/s12933-025-02700-0
narrative_reviewCited 15×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Semaglutide (1.0 mg/week) significantly reduces major kidney disease events, slows eGFR decline, and lowers MACE risk in patients with type 2 diabetes and chronic kidney disease.Strong
- Tirzepatide (up to 15 mg/week) reduces the risk of worsening heart failure and cardiovascular death in patients with heart failure with preserved ejection fraction (HFpEF) and obesity.Strong
- Empagliflozin (10 mg/day) does not significantly reduce the primary composite endpoint of hospitalization for heart failure or death from any cause in patients hospitalized with acute myocardial infarction.Strong
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