Hormonal
Defective hypothalamic autophagy promotes obesity and insulin resistance by activating the IKKβ/NF-κB inflammatory pathway, leading to increased energy intake and reduced energy expenditure.
Maintaining healthy autophagy in the brain may be important for metabolic health. While direct interventions are not specified, lifestyle factors that support cellular health (like exercise and balanced nutrition) might help maintain hypothalamic autophagy, thereby supporting normal energy balance and preventing obesity-related inflammation.
defective hypothalamic autophagy led to hypothalamic inflammation, including the activation of proinflammatory IκB kinase (κ) pathway... These metabolic changes were sufficient to increase energy intake and reduced energy expenditure.
Why this rating
Strong mechanistic evidence using specific knockout models and viral shRNA in mice, though translational to humans is not directly tested.
Source
Defective Hypothalamic Autophagy Directs the Central Pathogenesis of Obesity via the IκB Kinase β (IKKβ)/NF-κB Pathway
Qingyuan Meng et al. · Journal of Biological Chemistry · 2011
DOI 10.1074/jbc.m111.254417
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