Hormonal
Tirzepatide treatment is associated with a higher incidence of gastrointestinal adverse events (nausea, diarrhea, vomiting) compared to placebo and insulin, and slightly higher than GLP-1 RAs, though serious adverse events are not significantly different from placebo.
Expect gastrointestinal side effects like nausea, diarrhea, or vomiting, especially when starting or increasing the dose. These are usually mild and go away. Serious side effects (like pancreatitis or heart issues) did not show a statistically significant increase compared to placebo in this analysis. Monitor your symptoms and report severe or persistent issues to your doctor.
In terms of safety, compared with the placebo and insulin groups, the incidence of gastrointestinal adverse reactions was markedly higher in the tirzepatide group, slightly higher to the GLP-1 RAs group... The incidence of other adverse events, including pancreatitis, cholecystitis, major adverse cardiovascular events-4, hypersensitivity reactions, and neoplasms did not show significant statistical differences compared to the control group
Why this rating
Meta-analysis of 12 RCTs.
Source
Tirzepatide as a novel effective and safe strategy for treating obesity: a systematic review and meta-analysis of randomized controlled trials
Wenting Cai et al. · Frontiers in Public Health · 2024
DOI 10.3389/fpubh.2024.1277113
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