Research
Hormonal
Ketone bodies, specifically beta-hydroxybutyrate (BHB), have complex, potentially contradictory effects on appetite regulation by influencing AMPK phosphorylation and GABA levels, which may counteract hunger suppression.
Be aware that ketones might trigger some hunger signals via AMPK and GABA, but in practice, the hormonal suppression of ghrelin usually wins out, leading to net hunger reduction.
ModerateQualifiesMEDIUM confidence
ketone bodies (KB) seem to be able to increase food intake through AMP-activated protein kinase (AMPK) phosphorylation, gamma-aminobutyric acid (GABA) and the release and production of adiponectin.
Why this rating
Review paper discussing conflicting animal and human data.
Source
Ketosis, ketogenic diet and food intake control: a complex relationship
Antonio Paoli et al. · Frontiers in Psychology · 2015
DOI 10.3389/fpsyg.2015.00027
narrative_reviewCited 256×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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