Hormonal
Genetic variants at the SHBG locus and multiple other loci (including GCKR, LHCGR, and UGT2B15) significantly influence circulating sex hormone-binding globulin (SHBG) concentrations, with effects that are often sex-differentiated.
Your SHBG levels are partly determined by your DNA, specifically variants near genes like SHBG, GCKR, and LHCGR. This genetic background influences how your body handles testosterone and estrogen. While you cannot change your genetics, this knowledge highlights why SHBG is a critical marker for metabolic health and hormone-sensitive cancer risk.
We identified twelve genomic regions (SNPs) associated with circulating SHBG concentrations... These genes encompass multiple biologic pathways... We found evidence of sex-differentiated genetic influences on SHBG.
Why this rating
Large-scale GWAS meta-analysis with validation cohorts (n > 28,000).
Source
A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone–Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation
Andrea D. Coviello et al. · PLoS Genetics · 2012
DOI 10.1371/journal.pgen.1002805
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