Research
Adherence
Leptin administration in leptin-deficient patients normalizes brain activation patterns in response to food cues, reducing the motivational salience of food.
Leptin treatment doesn't just burn fat; it changes how your brain perceives food. Within days of starting treatment, the brain's reward response to food images normalizes, making it easier to resist food cues even before significant weight loss occurs.
GoodSupportsHIGH confidence
In the leptin-deficient state, images of food... were associated with a marked increase in neuronal activation in the anteromedial ventral striatum... This response was normalised by 7 days of leptin treatment, before weight loss occurred.
Why this rating
Based on fMRI studies in a small number of patients (n=2 mentioned for fMRI, larger for clinical outcomes).
Source
20 YEARS OF LEPTIN: Human disorders of leptin action
I Sadaf Farooqi et al. · Journal of Endocrinology · 2014
narrative_reviewCited 253×
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