Macro partitioning
Overexpression of the transcriptional coactivator PGC-1α in skeletal muscle increases glucose uptake and glycogen storage while suppressing glycolytic flux, thereby preventing glycogen depletion during exercise.
PGC-1α is a key protein induced by exercise that helps muscles store more glycogen and take up more glucose. This mechanism helps prevent glycogen depletion during exercise and aids in recovery. While you cannot directly 'dose' PGC-1α, engaging in exercise that induces PGC-1α (like endurance or high-intensity training) supports this metabolic adaptation.
Forced expression of PGC-1α increased muscle glucose uptake concomitant with augmentation of glycogen stores... Induction of muscle PGC-1α expression prevented muscle glycogen depletion during exercise.
Why this rating
High-quality mechanistic evidence using conditional transgenic and knockout mouse models with rigorous biochemical assays.
Source
A Role for the Transcriptional Coactivator PGC-1α in Muscle Refueling
Adam R. Wende et al. · Journal of Biological Chemistry · 2007
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