Research
Hormonal
Adipose tissue-specific deletion of AMPK alpha subunits impairs cold-induced thermogenesis and mitochondrial biogenesis in inguinal white adipose tissue, leading to cold intolerance and exacerbated obesity on a high-fat diet.
This finding underscores the importance of maintaining healthy metabolic signaling in fat cells. While you cannot delete your AMPK genes, regular physical activity is known to activate AMPK, potentially supporting the browning of fat and metabolic health.
GoodRefutesHIGH confidence
These AKO mice were cold intolerant and their inguinal WAT displayed impaired mitochondrial integrity and biogenesis, and reduced expression of thermogenic markers upon cold exposure. High-fat-diet (HFD)-fed AKO mice exhibited increased adiposity and exacerbated hepatic steatosis and fibrosis and impaired glucose tolerance and insulin sensitivity.
Why this rating
Robust genetic knockout model with detailed mechanistic analysis.
Source
AMP-Activated Protein Kinase (AMPK) Regulates Energy Metabolism through Modulating Thermogenesis in Adipose Tissue
Lingyan Wu et al. · Frontiers in Physiology · 2018
DOI 10.3389/fphys.2018.00122
mechanism_onlyCited 252×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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