Hormonal
Endothelial cell CD36 acts as a gatekeeper for tissue fatty acid uptake; its deletion reduces lipid accumulation in heart and muscle, which shifts tissue metabolism toward glucose utilization and improves systemic insulin sensitivity.
This research suggests that how your body transports fat (specifically via endothelial CD36) influences your insulin sensitivity. While you cannot directly 'dose' this gene, the findings imply that strategies which reduce excessive lipid accumulation in muscle (lipotoxicity) may improve insulin sensitivity. This supports the concept that metabolic health is heavily dependent on tissue fuel selection (fat vs. glucose) rather than just caloric intake.
In conclusion, EC CD36 acts as a gatekeeper for parenchymal cell FA uptake, with important downstream effects on glucose utilization and insulin action.
Why this rating
High-quality animal models (knockout mice) with rigorous metabolic phenotyping (PET scans, OGTT, ITT), though not directly translatable to human dosing.
Source
Endothelial cell CD36 optimizes tissue fatty acid uptake
Ni-Huiping Son et al. · Journal of Clinical Investigation · 2018
DOI 10.1172/jci99315
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