Hormonal
Continuous subcutaneous insulin infusion (insulin pump therapy) is associated with significantly lower cardiovascular mortality and all-cause mortality compared to multiple daily insulin injections in patients with type 1 diabetes.
For individuals with type 1 diabetes, switching from multiple daily injections to an insulin pump therapy is associated with a significantly reduced risk of fatal cardiovascular events and all-cause mortality. This benefit persists even after adjusting for various risk factors, suggesting that the precision of continuous insulin delivery may offer superior long-term protection compared to injection regimens.
Among people with type 1 diabetes use of insulin pump therapy is associated with lower cardiovascular mortality than treatment with multiple daily insulin injections.
Why this rating
Large observational study (n=18,168) with robust statistical adjustment (propensity scores), but limited by missing data on patient education and monitoring frequency.
Source
Insulin pump therapy, multiple daily injections, and cardiovascular mortality in 18 168 people with type 1 diabetes: observational study
Isabelle Isa Kristin Steineck et al. · BMJ · 2015
DOI 10.1136/bmj.h3234
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