Hormonal
Recombinant human growth hormone (rhGH) supplementation does not augment muscle strength gains in elderly men undergoing resistance training, despite increasing lean body mass and decreasing fat mass.
If you are an older man looking to get stronger, resistance training is the most effective strategy. Taking growth hormone will not give you extra strength gains compared to training alone, even though it might change your body composition slightly. Do not rely on GH for strength; focus on progressive resistance exercise.
Supplementation with rhGH does not augment the response to strength training in elderly men. These results suggest that deficits in GH secretion do not underlie the time-dependent leveling off of muscle strength seen with training in the elderly and provide no support in the popular view of GH as an ergogenic aid.
Why this rating
Double-blind, placebo-controlled trial with healthy elderly men, though limited by sample size (n=18) and duration (24 weeks).
Source
Effect of recombinant human growth hormone on the muscle strength response to resistance exercise in elderly men.
Dennis R. Taaffe et al. · The Journal of Clinical Endocrinology & Metabolism · 1994
DOI 10.1210/jcem.79.5.7525633
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →