Hormonal
Daily supplementation with 2000 IU of Vitamin D3 reduces the incidence of advanced (metastatic or fatal) cancer in adults without prior cancer diagnosis, with the effect being statistically significant only in individuals with a normal body mass index (BMI < 25).
If you are maintaining a healthy weight (BMI < 25), taking 2000 IU of Vitamin D3 daily may help reduce your risk of developing advanced or fatal cancer. However, if you are overweight or obese, this specific dose may not provide the same protective benefit against advanced cancer, likely due to how fat stores sequester the vitamin. Consult your doctor before starting, especially if you have existing health conditions.
a significant reduction in advanced cancers (metastatic or fatal) was found for those randomized to vitamin D compared with placebo... When stratified by BMI, there was a significant reduction for the vitamin D arm in incident metastatic or fatal cancer among those with normal BMI (BMI<25: HR, 0.62 [95% CI, 0.45-0.86]) but not among those with overweight or obesity
Why this rating
Randomized, double-blind, placebo-controlled trial with large sample size (N=25,871) and long follow-up (median 5.3 years), though secondary analysis.
Source
Effect of Vitamin D<sub>3</sub> Supplements on Development of Advanced Cancer
Paulette D. Chandler et al. · JAMA Network Open · 2020
DOI 10.1001/jamanetworkopen.2020.25850
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