Research
Macro partitioning
High-fat diets contribute to positive energy balance by increasing hunger levels and reducing 24-hour plasma leptin concentrations, unlike high-carbohydrate meals.
Be aware that high-fat meals can increase your hunger and reduce satiety hormones like leptin more than high-carb meals. This makes it harder to stop eating. Prioritize foods that support satiety signaling rather than just counting calories.
GoodSupportsHIGH confidence
High-fat meals actually reduce 24-hour plasma leptin concentrations... a high-fat intake contributes to a positive energy balance directly by increasing the amount of energy consumed... and also by increasing the drive to eat through increased hunger levels.
Why this rating
Supported by cited studies showing physiological differences in leptin response and hunger between high-fat and high-carb meals.
Source
Control of Food Intake in the Obese
John E. Blundell et al. · Obesity Research · 2001
DOI 10.1038/oby.2001.129
narrative_reviewCited 249×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Human body weight regulation is asymmetrical: the system strongly defends against weight loss (negative energy balance) but tolerates positive energy balance, leading to obesity in obesogenic environments.Good
- Low leptin levels after weight loss act as a biological risk factor that increases hunger and reduces satiety signaling, promoting weight regain.Good
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