Hormonal
Testosterone substitution normalizes elevated serum leptin levels in hypogonadal men, with the androgen-to-estrogen ratio serving as the primary determinant of leptin production.
If you are a man with clinically low testosterone, your body may be producing excess leptin, which can interfere with weight management and metabolic health. Restoring testosterone to normal levels through medical substitution therapy can normalize these leptin levels, potentially improving your body's ability to regulate energy balance and fat storage.
We conclude that hypogonadal men exhibit elevated OB levels that are normalized by substitution with T. The only determinant of OB levels was the androgen/estrogen ratio, indicating a major influence of sex steroids on OB production.
Why this rating
Randomized controlled trial with clear endpoints, though the sample size is small (n=22).
Source
Testosterone Substitution Normalizes Elevated Serum Leptin Levels in Hypogonadal Men
F. Jockenhövel et al. · The Journal of Clinical Endocrinology & Metabolism · 1997
DOI 10.1210/jcem.82.8.4174
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