Research
Hormonal
Orexin neurons are sensitive to metabolic cues such as glucose, leptin, and ghrelin, linking energy homeostasis with vigilance states.
Regular meals and balanced nutrition support orexin function, which in turn supports wakefulness and energy levels. Avoid skipping meals, especially breakfast.
GoodSupportsHIGH confidence
The responsiveness of orexin neurons to peripheral metabolic cues suggests that these neurons have an important role as a link between energy homeostasis and vigilance states.
Why this rating
Strong evidence from animal studies, but human data is less direct.
Source
Role of orexin in modulating arousal, feeding, and motivation
Natsuko Tsujino et al. · Frontiers in Behavioral Neuroscience · 2013
DOI 10.3389/fnbeh.2013.00028
narrative_reviewCited 249×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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