Research
Hormonal
Sibutramine (5-20 mg/day) produces significant weight loss and metabolic improvements in obese patients with controlled hypertension, but causes small, statistically significant increases in blood pressure and heart rate.
Sibutramine can help obese patients with controlled hypertension lose weight and improve metabolic markers, but it requires careful monitoring of blood pressure and heart rate. The benefits of weight loss generally outweigh the small increases in vital signs for this specific population.
GoodQualifiesHIGH confidence
For patients receiving sibutramine, weight loss occurred during the first 6 months of the trial and was maintained to the end of the 12-month treatment period... Sibutramine-treated patients had small but statistically significant mean increases in diastolic blood pressure (2.0 mm Hg) and pulse rate (4.9 beats/min) compared with placebo-treated patients
Why this rating
Double-blind, placebo-controlled, multicenter trial with 52-week duration.
Source
Efficacy and Safety of Sibutramine in Obese White and African American Patients With Hypertension
F. Gilbert McMahon et al. · Archives of Internal Medicine · 2000
DOI 10.1001/archinte.160.14.2185
rct · n=224Cited 247×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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