Research
Hormonal
Obese individuals exhibit attenuated postprandial responses of satiety hormones (GLP-1, PYY) compared to lean individuals, which correlates with lower subjective fullness and potentially contributes to overconsumption.
Obese individuals may experience less fullness after meals due to blunted satiety hormone responses. This is a biological factor, not just a lack of willpower. Strategies that naturally boost these hormones (like high-protein/fat meals or exercise) may help.
GoodSupportsHIGH confidence
Obesity has been associated with an attenuated postprandial GLP-1 response to test meals... Several studies have documented the obesity-related attenuation of postprandial responses in PYY levels... This attenuated response corresponded with significantly lower subjective ratings of fullness in obese subjects.
Why this rating
Based on multiple RCTs and observational studies cited in the review.
Source
Altered gut and adipose tissue hormones in overweight and obese individuals: cause or consequence?
MEJ Lean et al. · International Journal of Obesity · 2015
DOI 10.1038/ijo.2015.220
narrative_reviewCited 246×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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