Hormonal
Concurrent strength and endurance training interferes with maximal strength development when both modalities engage the same muscle groups, primarily due to antagonistic intracellular signaling where AMPK activation inhibits mTOR.
If your primary goal is maximizing strength, be aware that adding endurance training (like running or cycling) in the same session or on the same days can blunt your strength gains. This is due to conflicting signals in your muscle cells. To fix this, separate your strength and endurance sessions by at least 6-8 hours, or prioritize one modality on specific days.
activation of AMPK by endurance exercise may inhibit signaling to the protein-synthesis machinery by inhibiting the activity of mTOR and its downstream targets.
Why this rating
Based on a review of multiple studies (Hickson, Dudley, Kraemer) and molecular mechanisms, though some studies show no interference.
Source
Concurrent Strength and Endurance Training
Gustavo A. Nader · Medicine & Science in Sports & Exercise · 2006
DOI 10.1249/01.mss.0000233795.39282.33
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