Hormonal
Hepatic Stearoyl-CoA Desaturase 1 (SCD1) activity is significantly increased in human fatty liver and positively correlates with liver fat content and diacylglycerol concentrations.
High SCD1 activity is a hallmark of fatty liver in humans. This enzyme helps convert saturated fats into monounsaturated fats (like oleic acid). The study shows that as liver fat increases, SCD1 activity increases. This suggests that dietary fats high in saturated fatty acids might fuel this process, leading to more monounsaturated fats and subsequently more triglycerides/DAGs in the liver.
Liver fat percent was positively related to hepatic stearoyl-CoA desaturase 1 (SCD1) activity index (r = 0.70, P = 0.003)... Hepatic SCD1 activity index was positively related to the concentrations of diacylglycerols (r = 0.71, P = 0.002).
Why this rating
Strong correlation (r=0.70) but small sample size (n=16).
Source
Hepatic Stearoyl-CoA Desaturase (SCD)-1 Activity and Diacylglycerol but Not Ceramide Concentrations Are Increased in the Nonalcoholic Human Fatty Liver
Anna Kotronen et al. · Diabetes · 2008
DOI 10.2337/db08-1074
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →